Epitopes of the Mycobacterial Heat Shock Protein 65 for Human T Cells Comprise Different Structures
β Scribed by Munk, Martin E.; Shinnick, Thomas M.; Kaufmann, Stefan H.E.
- Book ID
- 123070243
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 336 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0171-2985
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π SIMILAR VOLUMES
## DR3-restricted T cells from different HLA-DR3-positive individuals recognize the same peptide (amino acids 2-12) of the mycobacterial 65-kDa heat-shock protein* Studies in experimental animals have demonstrated that the T cell response to immunogenic proteins is limited to one or a few epitopes
## Abstract A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65βkDa heatβshock protein (hsp) as a putative causal agent. The 65βkDa hsp has over 40% sequence homology with the human hsp 60, a