P53 alteration correlates with negative
P53 alteration correlates with negative ER, negative PGR, and high histologic grade in breast cancer
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Mitsunori Sasa; Kazuya Kondo; Kansei Komaki; Tadaoki Morimoto; Yasumasa Monden
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Article
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1994
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John Wiley and Sons
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English
⚖ 394 KB
Seventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT-PCR-SSCP method. Sixty-five samples (92.9%) were investigated in the regions of codons 101-200 and 201-300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration