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Epithelial-specific requirement of FGFR2 signaling during tooth and palate development

✍ Scribed by Ryoichi Hosokawa; Xuemei Deng; Kazunori Takamori; Xun Xu; Mark Urata; Pablo Bringas Jr; Yang Chai

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 605 KB
Volume: 312B
Category: Article
ISSN: 1552-5007
DOI: 10.1002/jez.b.21274

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✦ Synopsis

Abstract

Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial–mesenchymal tissue interaction. We have generated epithelial‐specific conditional knockout mice targeting Fibroblast growth factor receptor 2 (Fgfr2) to investigate the function of FGF signaling during craniofacial development. K14‐Cre;Fgfr2^fl/fl^ mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of K14‐Cre;Fgfr2^fl/fl^ mice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development. J. Exp. Zool. (Mol. Dev. Evol.) 312B:343–350, 2009. © 2009 Wiley‐Liss, Inc.

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