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Epithelial-mesenchymal transdifferentiation and extracellular matrix gene expression in pleomorphic adenomas of the parotid salivary gland

✍ Scribed by Aigner, Thomas; Neureiter, Daniel; Völker, Uwe; Belke, Jutta; Kirchner, Thomas

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
888 KB
Volume
186
Category
Article
ISSN
0022-3417

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✦ Synopsis

Mesenchymal and epithelial cell differentiation are assumed to be dichotomic primary events in embryonic development. In this study, pleomorphic adenomas of the parotid gland were analysed as a model which shows morphological features of both epithelial and mesenchymal tissue types. Using matrix gene expression profiles as a supplementary criterion for the identification of cellular phenotypes, areas with unequivocal epithelial and mesenchymal differentiation could be demonstrated. Many areas displayed a transitional phenotype with cells showing both epithelial and mesenchymal features. The data provide evidence that epithelialmesenchymal transitions represent the basic principle of the tisuse heterogeneity in pleomorphic adenomas. Thus, pleomorphic adenomas demonstrate the potential of adult (neoplastic) epithelial cells to transdifferentiate into mesenchymal cells in vivo. 1998 John Wiley & Sons, Ltd.

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