Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2/neu Mice
β Scribed by V. N. Anisimov; V. Kh. Khavinson; I. N. Alimova; A. V. Semchenko; A. I. Yashin
- Book ID
- 110403668
- Publisher
- Springer US
- Year
- 2002
- Tongue
- English
- Weight
- 429 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0007-4888
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## Abstract The effect of various regimens of treatment with melatonin on the development of mammary tumors in HER2/neu transgenic mice was investigated. Female HERβ2/neu mice starting from the age of 2 months were kept under standard light/dark regimen and as given melatonin with tap water (20 mg/
Female FVB/N HER-2/neu transgenic mice from the age of 2 months were subcutaneously injected with saline, the peptide Epitalon(R) (Ala-Glu-Asp-Gly) or with the peptide Vilon(R) (Lys-Glu) in a single dose of 1 microg/mouse for 5 consecutive days every month. Epitalon treatment reduced the cumulative