MRI estimations of cerebral blood volume (CBV), useful in mapping brain dysfunction, typically require intravenous (IV) injections of contrast agents. Transgenically engineered mice have emerged as the dominant animal model with which to investigate disorders of the brain and novel therapeutic agent
EPISTAR MRI: Multislice mapping of cerebral blood flow
β Scribed by Robert R. Edelman; Qun Chen
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 691 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
A method is described for multislice EPISTAR that perfectly compensates magnetization transfer effects. lnflowing arterial spins are labeled with a 360Β° adiabatic pulse. Two control tags are applied sequentially at the same location as the labeling pulse, each with a 180Β° adiabatic pulse so the total RF irradiation, frequency shift, and bandwidth of the labeling and control pulses are identical. Therefore, magnetization transfer effects are the same as for the labeling pulse and cancel with image subtraction for all slices. The method also eliminates tagging of venous spins and concern about asymmetric magnetization transfer effects.
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