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Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K–PDK1 signaling

✍ Scribed by Ying Zhang; Ekaterina Shumilina; Hans-Ulrich Häring; Florian Lang; Susanne Ullrich


Book ID
113621541
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
551 KB
Volume
583
Category
Article
ISSN
0014-5793

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## Abstract Phosphatidylinositol 3‐kinase (PI3K) signaling controls survival and proliferation of cancer cells and is activated in around 60% of pancreatic ductal adenocarcinomas (PDACs). Although not entirely clarified, PI3K signaling is linked to cell cycle progression of PDAC cells. In this stud