Epilepsy: Models, Mechanisms and Concepts

✍ Scribed by Philip A. Schwartzkroin (editor)

• Publisher: Cambridge University Press
• Year: 2007
• Tongue: English
• Leaves: 559
• Edition: 1
• Category: Library

✦ Synopsis

Advances in epilepsy research are occurring at a rapid rate, resulting in a bewildering wealth of data. The implications of this new knowledge for future research and clinical practice can be confusing. This volume concentrates on the concepts and models of epilepsy that have been developed as a result of this research. Written by prominent researchers in the field, it describes and discusses the relevant models used to address critical questions, and reviews the most up-to-date issues. Chapters focus on the pathways and mechanisms through which seizure activity is initiated and spread, in both normal and abnormal brain tissues, and discuss the special properties of epileptogenesis in the immature brain. In a field in which rapid advances lead to constant update of empirical data, this book takes a conceptual approach to the subject and provides a solid framework within which to understand the emerging issues.

✦ Table of Contents

Cover......Page 1
Frontmatter......Page 2
Contents......Page 10
List of contributors......Page 12
General introduction......Page 16
Section 1 - Chronic models in intact animals -- concepts and questions......Page 34
Introduction......Page 35
1 - The kindling model of epilepsy......Page 42
2 - Focal trigger zones and pathways of propagation in seizure generation......Page 63
3 - Genetic models of the epilepsies......Page 109
4 - Noradrenergic modulation of excitability: transplantation approaches to epilepsy research......Page 156
5 - Sensitivity of the immature central nervous system to epileptogenic stimuli......Page 186
Section 2 - Features of the epileptogenic brain......Page 214
Introduction......Page 215
6 - Neurophysiological studies of alterations in seizure susceptibility during brain development......Page 224
7 - Electrophysiology and pharmacology of human neocortex and hippocampus in vitro......Page 259
8 - Cell death, plasticity, and epilepsy: insights provided by experimental models of hippocampal sclerosis......Page 296
9 - Sprouting as an underlying cause of hyperexcitability in experimental models and in the human epileptic temporal lobe......Page 319
10 - Rapidly recurring seizures and status epilepticus: ictal density as a factor in epileptogenesis......Page 338
Section 3 - `Normal' brain mechanisms that support epileptiform activities......Page 372
Introduction......Page 373
11 - Brain slice models for the study of seizures and interictal spikes......Page 386
12 - Generation of epileptiform discharge by local circuits of neocortex......Page 403
13 - Study of GABAergic inhibition and GABAA receptors in experimental epilepsy......Page 439
14 - High potassium-induced synchronous bursts and electrographic seizures......Page 452
15 - Anti-epileptic effects of organic calcium channel blockers in animal experiments......Page 477
Recent advances......Page 502
Index......Page 544

✦ Subjects

Медицинские дисциплины;Физиология человека;