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Epigenomics in respiratory epithelium carcinogenesis: Prevention and therapeutic challenges

✍ Scribed by Michalis V. Karamouzis; Panagiotis A. Konstantinopoulos; Athanasios G. Papavassiliou

Book ID
116395112
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
175 KB
Volume
33
Category
Article
ISSN
0305-7372

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## Abstract The enhancement of chemical carcinogenesis was demonstrated __in vitro__ in rat tracheal epithelium exposed in organ culture to N′‐methyl‐N′‐nitro‐N‐nitroso‐guanidine (MNNG) followed by multiple exposures to 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA). The explants were exposed to 0 or