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Epigenome Mapping in Normal and Disease States

✍ Scribed by Maunakea, A. K.; Chepelev, I.; Zhao, K.; Bruneau, B.

Book ID
115453791
Publisher
Lippincott Williams and Wilkins
Year
2010
Tongue
English
Weight
489 KB
Volume
107
Category
Article
ISSN
0009-7330

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There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors.

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## Abstract The epigenome consists of the DNA methylation marks and histone modifications involved in controlling gene expression. It is accurately reproduced during mitosis and can be inherited transgenerationally. The innate plasticity of the epigenome also enables it to be reprogrammed by nutrit