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Epigenetics: Actors in the cell reprogramming drama

✍ Scribed by Loh, Kyle M.; Lim, Bing


Book ID
115453402
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
860 KB
Volume
488
Category
Article
ISSN
0028-0836

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## Abstract Tamoxifen, a nonsteroidal anti‐estrogen, is a potent genotoxic hepatocarcinogen in rats, with both tumor initiating and promoting properties. Recently it has been demonstrated that genotoxic carcinogens, in addition to exerting genotoxic effects, often cause epigenetic alterations and t