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Epigenetic targeting in the mouse zygote marks DNA for later methylation: a mechanism for maternal effects in development

✍ Scribed by Benjamin Pickard; Wendy Dean; Sabine Engemann; Kerstin Bergmann; Martina Fuermann; Martin Jung; Andre Reis; Nick Allen; Wolf Reik; Jörn Walter


Book ID
118602121
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
659 KB
Volume
103
Category
Article
ISSN
0925-4773

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## Abstract Summary: Genome‐wide epigenetic reprogramming by demethylation occurs in early mouse embryos and primordial germ cells. In early embryos many single‐copy sequences become demethylated both by active and passive demethylation, whereas imprinted gene methylation remains unaffected. In pri