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Epigenetic silencing of CHD5 , a novel tumor-suppressor gene, occurs in early colorectal cancer stages

✍ Scribed by Fatemi, Mehrnaz; Paul, Thomas A.; Brodeur, Garrett M.; Shokrani, Babak; Brim, Hassan; Ashktorab, Hassan


Book ID
124091044
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
530 KB
Volume
120
Category
Article
ISSN
0008-543X

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## Abstract Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome‐wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylate