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Epigenetic regulation of the maize Spm transposon

✍ Scribed by Nina Fedoroff; Michael Schläppi; Ramesh Raina

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
814 KB
Volume
17
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Expression and transposition of the Suppressormutator (Spm) transposon of maize are controlled by interacting epigenetic and autoregulatory mechanisms. Methylation of critical element sequences prevents both transcription and transposition, heritably inactivating the element. The promoter, comprising the terminal 0.2 kb of the element, and a 0.35-kb, highly GC-rich, downstream sequence are the methylation target sequences. The element encodes two proteins necessary for transposition, TnpA and TnpD. There are multiple TnpA binding sites, both in the 5' terminal promoter region and at the element's 3' end. In addition to its role in transposition, TnpA is both a positive and a negative regulator of transcription. TnpA represses the element's promoter when it is not methylated. When the element is inactive and its promoter methylated, TnpA activates the methylated promoter and facilitates both its demethylation.

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