Gene expression is controlled by epigenetic mechanisms such as histone acetylation and methylation, and recent studies have revealed that key developmental steps are regulated by the trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3). Using ChIP sequencing technology combined w
β¦ LIBER β¦
Epigenetic regulation of osteoclast differentiation
β Scribed by Tetsuro Yasui; Jun Hirose; Hiroyuki Aburatani; Sakae Tanaka
- Book ID
- 111400288
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 645 KB
- Volume
- 1240
- Category
- Article
- ISSN
- 0890-6564
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## Abstract Although osteopontin (OPN) is highly expressed in osteoclasts, OPNβdeficient mice have a nearβnormal bone phenotype and its role in osteoclast differentiation and function remains uncertain. We used an adenoviral OPNβantisense vector (AdOPNβAS) to downβregulate OPN expression in a human