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Epigenetic regulation of osteoclast differentiation

✍ Scribed by Tetsuro Yasui; Jun Hirose; Hiroyuki Aburatani; Sakae Tanaka


Book ID
111400288
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
645 KB
Volume
1240
Category
Article
ISSN
0890-6564

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## Abstract Although osteopontin (OPN) is highly expressed in osteoclasts, OPN‐deficient mice have a near‐normal bone phenotype and its role in osteoclast differentiation and function remains uncertain. We used an adenoviral OPN‐antisense vector (AdOPN‐AS) to down‐regulate OPN expression in a human