Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
β Scribed by Baba, T; Convery, P A; Matsumura, N; Whitaker, R S; Kondoh, E; Perry, T; Huang, Z; Bentley, R C; Mori, S; Fujii, S
- Book ID
- 109970706
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 575 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0950-9232
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Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. CD133, a transmembrane glycoprotein, is an important cell surface marker for both stem cells and cancer stem cells in various tissues including liver. CD133 expression has been recently linked to poor prognosis
## Abstract The transmembrane protein CD133 and its extracellular epitope AC133 are controversial cancer markers. In glioma, AC133 demarcates a subpopulation of stemβlike tumor cells, soβcalled cancer stem cells (CSCs), which seem to drive tumor formation and are highly resistant to conventional ch