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Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

✍ Scribed by Hemberger, Myriam; Dean, Wendy; Reik, Wolf

Book ID: 109959209
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 707 KB
Volume: 10
Category: Article
ISSN: 1471-0072
DOI: 10.1038/nrm2727

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## Abstract Stem cells are thought to inhabit in a unique microenvironment, known as “niche,” in which they undergo asymmetric cell divisions that results in reproducing both stem cells and progenies to maintain various tissues throughout life. The cells of osteoblastic lineage have been identified