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Epigenetic drugs as immunomodulators for combination therapies in solid tumors

โœ Scribed by Sigalotti, Luca; Fratta, Elisabetta; Coral, Sandra; Maio, Michele


Book ID
121461684
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
881 KB
Volume
142
Category
Article
ISSN
0163-7258

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## Abstract ## BACKGROUND. Innovative epigenetic therapeutics comprise histone deacetylase inhibitors (HDACโ€I) and demethylating agents (DA). It was recently found that HDACโ€I compounds exhibit profound therapeutic activities against hepatocellular carcinoma (HCC). A comprehensive preclinical inve