Epigenetic alterations of CDH1 and APC genes: Relationship with activation of Wnt/β-catenin Pathway in invasive ductal carcinoma of breast

Epigenetic and genetic alterations of AP

Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: Relationships with abnormal E-cadherin and catenin expression and microsatellite instability

✍ David Sarrió; Gema Moreno-Bueno; David Hardisson; Carolina Sánchez-Estévez; Ming 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 373 KB

## Abstract The causes and functional consequences of E‐cadherin (E‐CD) loss in breast cancer are poorly understood. E‐CD loss might act in concert with alterations in the APC/β‐catenin pathway to permit oncogenic β‐catenin signaling. To test this hypothesis, we have analyzed the presence of geneti