Epigenetic Alterations in Oncogenesis

✍ Scribed by Bilian Jin, Keith D. Robertson (auth.), Adam R. Karpf (eds.)

Publisher: Springer-Verlag New York
Year: 2013
Tongue: English
Leaves: 1064
Series: Advances in Experimental Medicine and Biology 754
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

✦ Table of Contents

Front Matter....Pages i-xv
Front Matter....Pages 1-1
DNA Methyltransferases, DNA Damage Repair, and Cancer....Pages 3-29
DNA Hypomethylation and Hemimethylation in Cancer....Pages 31-56
Ten Eleven Translocation Enzymes and 5-Hydroxymethylation in Mammalian Development and Cancer....Pages 57-79
Altered Histone Modifications in Cancer....Pages 81-107
Nucleosome Occupancy and Gene Regulation During Tumorigenesis....Pages 109-134
Front Matter....Pages 135-135
Epigenetic Regulation of miRNAs in Cancer....Pages 137-148
DNA Hypomethylation and Activation of Germline-Specific Genes in Cancer....Pages 149-166
APC and DNA Demethylation in Cell Fate Specification and Intestinal Cancer....Pages 167-177
Epigenetic Changes During Cell Transformation....Pages 179-194
Epigenetic Reprogramming of Mesenchymal Stem Cells....Pages 195-211
Front Matter....Pages 213-213
Environmental Toxicants, Epigenetics, and Cancer....Pages 215-232
Blood-Derived DNA Methylation Markers of Cancer Risk....Pages 233-252
Epigenetic Therapies in MDS and AML....Pages 253-283
Epigenetic Targeting Therapies to Overcome Chemotherapy Resistance....Pages 285-311
Methods for Cancer Epigenome Analysis....Pages 313-338
Back Matter....Pages 339-348

✦ Subjects

Cancer Research; Human Genetics; Oncology

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