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(−)-Epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts

✍ Scribed by Junichi Yamauchi; Shinji Takai; Rie Matsushima-Nishiwaki; Yoshiteru Hanai; Tomoaki Doi; Hisaaki Kato; Shinji Ogura; Kanefusa Kato; Haruhiko Tokuda; Osamu Kozawa


Book ID
116838594
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
480 KB
Volume
77
Category
Article
ISSN
0952-3278

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We previously reported that prostaglandin F 2␣ (PGF 2␣ ) activates both phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells and then induces the activation of protein kinase C (PKC). In this study, we investigated the eff