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Epigallocatechin gallate inhibits HIF-1α degradation in prostate cancer cells

✍ Scribed by Rusha Thomas; Myoung H. Kim

Book ID
116290878
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
466 KB
Volume
334
Category
Article
ISSN
0006-291X

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## Abstract We previously showed that treatment of prostate cancer cells with soy isoflavones and radiation resulted in greater cell killing __in vitro,__ and caused downregulation of NF‐κB and APE1/Ref‐1. APE1/Ref‐1 functions as a redox activator of transcription factors, including NF‐κB and HIF‐1