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(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

✍ Scribed by Guo-Qing Tang; Tai-Qiang Yan; Wei Guo; Ting-Ting Ren; Chang-Liang Peng; Hui Zhao; Xin-Chang Lu; Fu-Long Zhao; Xiaoguang Han


Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
743 KB
Volume
136
Category
Article
ISSN
1432-1335

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Chondrosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been shown to inhibit tumorigenesis and cancer cell growth in animal models. The aim of this study was to el