𝔖 Bobbio Scriptorium
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Epidermis generated in vitro: practical considerations and applications

✍ Scribed by Nancy L. Parenteau; Cynthia M. Nolte; Patrick Bilbo; Mireille Rosenberg; Leon M. Wilkins; Eric W. Johnson; Stephen Watson; Valerie S. Mason; Eugene Bell

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
652 KB
Volume
45
Category
Article
ISSN
0730-2312

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✦ Synopsis

The technology for culture of epidermis is one of the most advanced to date for generation of a tissue in vitro. Cultured epidermis is already used for a number of applications ranging from use as a permanent skin replacement to use as an organotypic culture model for toxicity testing and basic research. While simple epidermal sheets have been grafted successfully, more advanced models for skin replacement consisting of both dermal and epidermal components are in development and being tested in a number of laboratories. One of t h e most advanced in vitro models is the living skin equivalent, an organotypic model consisting of a collagen lattice contracted and nourished by dermal fibroblasts overlaid with a fully formed epidermis.

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