✦ LIBER ✦

Epidermis and lymphocyte interactions during a tuberculin skin reaction

✍ Scribed by C. G. Larsen; T. Ternowitz; F. G. Larsen; K. Thestrup-Pedersen

Book ID: 104766969
Publisher: Springer-Verlag
Year: 1988
Tongue: English
Weight: 623 KB
Volume: 280
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00417709

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✦ Synopsis

Forty-one persons were tested for tuberculin skin reactivity. Epidermal cells (ECs) were isolated from the tuberculin reaction and from a contra lateral, non injected skin area. We found a significant increase of epidermal thymocyte activating factor (ETAF) in epidermis overlying a positive tuberculin reaction together with an increase of OKT6 and class II (HLA-DR) positive cells. Allogeneic lymphocytes proliferated significantly more when mixed with ECs from a positive tuberculin skin test. Injection of tuberculin per se or a negative reaction did not induce similar changes. The described model seems useful for functional studies of ECs and lymphocytes in patients with contact dermatitis.

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