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Epidermal growth factor receptor tyrosine kinase: Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor

✍ Scribed by Walter H.J. Ward; Peter N. Cook; Anthony M. Slater; D.Huw Davies; Geoffrey A. Holdgate; Leslie R'. Green


Book ID
115783782
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
1001 KB
Volume
48
Category
Article
ISSN
0006-2952

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## Abstract A range of target‐based agents for the treatment of solid tumors are in development. The epidermal growth factor receptor (EGFR) has been identified as a relevant target as it is involved in regulating several cellular functions important in the proliferation and survival of cancer cell