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Epidermal growth factor receptor R521K polymorphism shows favorable outcomes in KRAS wild-type colorectal cancer patients treated with cetuximab-based chemotherapy

✍ Scribed by Yao-Yu Hsieh; Cheng-Hwai Tzeng; Ming-Huang Chen; Po-Min Chen; Wei-Shu Wang


Book ID
114703200
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
306 KB
Volume
103
Category
Article
ISSN
1347-9032

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## Abstract Seventy to 40% of K‐RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti‐EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF‐1 system, altered activation colorectal cancer cells may escape anti‐EGF