Epidermal growth factor receptor is activated by hyposmolarity and is an early signal modulating osmolyte efflux pathways in Swiss 3T3 fibroblasts

Insulin-like growth factor-I-dependent s

Insulin-like growth factor-I-dependent stimulation of nuclear phospholipase C-β1 activity in Swiss 3T3 cells requires an intact cytoskeleton and is paralleled by increased phosphorylation of the phospholipase

✍ Alberto M. Martelli; Lucio Cocco; Renato Bareggi; Giovanna Tabellini; Riccardo R 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 1 views

Swiss 3T3 mouse fibroblasts were exposed to 10 microM colchicine to disrupt microtubules, then stimulated with insulin-like growth factor-I. Immunoprecipitation experiments showed that insulin-like growth factor-I receptor and insulin receptor substrate-1 were tyrosine phosphorylated to the same ext