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Epidermal growth factor receptor-induced activator protein 1 activity controls density-dependent growth inhibition in normal rat kidney fibroblasts

โœ Scribed by Jorrit J. Hornberg; Henk Dekker; Peter H. J. Peters; Petra Langerak; Hans V. Westerhoff; Jan Lankelma; Everardus J. J. van Zoelen

Book ID
111640555
Publisher
Humana Press Inc
Year
2006
Tongue
English
Weight
815 KB
Volume
34
Category
Article
ISSN
1073-6085

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Normal rat kidney (NRK) fibroblasts are immortalized cells that are strictly dependent on externally added growth factors for proliferation. When cultured in the presence of epidermal growth factor (EGF) as the only growth stimulating hormone, these cells have a normal phenotype and undergo density-