## Abstract ## BACKGROUND. Cleavage of membraneโanchored heparinโbinding epidermal growth factorโlike growth factor (proHBโEGF) yields a soluble HBโEGF isoform (sHBโEGF), which is an activating epidermal growth factor receptor (EGFR) ligand and a Cโterminal fragment HBโEGFโC acting directly in the
Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes
โ Scribed by Mothaffar F. Rimawi; Priya B. Shetty; Heidi L. Weiss; Rachel Schiff; C. Kent Osborne; Gary C. Chamness; Richard M. Elledge
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 231 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## BACKGROUND. Epidermal growth factor receptor (EGFR, HERโ1, and __erbB__1) is overexpressed in primary breast cancer and had been identified as a poor prognostic factor. ## METHODS. Pretreatment serum EGFR levels were quantified by using an enzymeโlinked immunoadsorbent assay in a