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Epidermal growth factor receptor (EGFR) and NF-ϰB regulate intestinal epithelial restitution in a novel motogenic cascade

✍ Scribed by Laurence Egan; Evan Lehrman; Ana De Lecea; Gennet Myhre; Lars Eckmann; Martin F. Kagnoff


Book ID
119427291
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
368 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract Inactivation of survival pathways such as NF‐κB, cyclooxygenase (COX‐2), or epidermal growth factor receptor (EGFR) signaling individually may not be sufficient for the treatment of advanced pancreatic cancer (PC) as suggested by recent clinical trials. 3,3′‐Diindolylmethane (B‐DIM) is