✦ LIBER ✦

Epidermal growth factor receptor and angiogenesis: Opportunities for combined anticancer strategies

✍ Scribed by Hester van Cruijsen; Giuseppe Giaccone; Klaas Hoekman

Publisher: John Wiley and Sons
Year: 2005
Tongue: French
Weight: 91 KB
Volume: 117
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.21479

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Tumor‐induced angiogenesis is essential for malignant growth. This mini review focuses on the role of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) and their receptors in this process, and the rationale to combine inhibitors of these growth factors as anticancer therapy. Concomitantly, targeting the VEGF(R) and the EGF(R) signaling pathway may circumvent the problem of acquired resistance to EGFR inhibitors. By targeting both pathways, the antiangiogenic effect may be more pronounced, which may lead to greater antitumor activity. Preliminary efficacy data from clinical trials encourage further exploration of this combined anticancer strategy. © 2005 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Adenomatous goitre: Therapeutic strategy

Adenomatous goitre: Therapeutic strategy, postoperative outcome, and study of epidermal growth factor receptor

✍ Dr. A. Sugenoya; H. Masuda; M. Komatsu; S. Yokoyama; T. Shimizu; M. Fujimori; S. 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

Receptors for epidermal growth factor an

Receptors for epidermal growth factor and estradiol in canine mammary tumors

✍ V. R. Nerurkar; Rajeshwari Seshadri; Rita Mulherkar; C. S. Ishwad; V. S. Lalitha 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 326 KB

Epidermal growth factor receptor-targete

Epidermal growth factor receptor-targeted treatment for advanced colorectal carcinoma

✍ Alan P. Venook 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB

Receptors for epidermal growth factor an

Receptors for epidermal growth factor and steroid hormones in primary colorectal tumors

✍ Giovanni Scambia; Pierluigi Benedetti Panici; Rocco Bellantone; Giovanni Battist 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 444 KB

The presence of epidermal growth factor, estrogen, and progesterone receptors (EGFR, ER, and PR) was investigated by a competitive binding assay in 43 colorectal adenocarcinomas and 32 normal colorectal mucosa specimens. EGFR were expressed in most of the tumor specimens analyzed at levels comparabl

Receptors for epidermal growth factor an

Receptors for epidermal growth factor and steroid hormones in primary laryngeal tumors

✍ Giovanni Scambia; Pierluigi Benedetti Panici; Francesco Battaglia; Gabriella Fer 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 563 KB

The authors investigated the presence of epidermal growth factor (EGF-R), estrogen (ER), progesterone (PR), and androgen (AR) receptors in 42 laryngeal squamous cell carcinomas and 20 normal laryngeal mucosa specimens. EGF-R were expressed in all tumor specimens analyzed, with significantly higher l

Reduced receptor expression for platelet

Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells

✍ Pamela L. Rice; Stephanie E. Porter; Kelli M. Koski; Gayatri Ramakrishna; Aaron 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB 👁 2 views

The roles of growth factors in mouse lung neoplasia were investigated by examining receptors for platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) in epithelial cell lines. Whereas nontumorigenic lung cells expressed mRNA and protein for PDGF receptor (PDGFR)-a, PDGFR-b, and EG