Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices
โ Scribed by Kazuho Abe; Fei-jun Xie; Hiroshi Saito
- Book ID
- 115801705
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 363 KB
- Volume
- 547
- Category
- Article
- ISSN
- 0006-8993
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Hippocampal long-term potentiation (LTP) is widely believed to be a cellular substrate for learning and memory. A likely physiological stimulus for initiating LTP is repetitive neuronal activity, which also results in K + accumulation extracellularly . Therefore, the involvement of elevated extracel
Long-term potentiation (LTP) was examined in the CA1 region of rat hippocampal slices at postnatal day 9 (P9), P15, P30, P60, P90, P120, and P300. A single 100 H z x 1 sec tetanus failed to induce LTP in P9 slices, while similar degrees of LTP were observed at P15, P30, and P60. At P30, changes in p