Epidermal growth factor: a necessary stimulus to trigger the emergence of a new epithelial cell type from renal glomeruli

Hepatocyte growth factor preferentially

Hepatocyte growth factor preferentially activates the anti-inflammatory arm of NF-κB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation

✍ Cleide G. da Silva; Elizabeth R. Maccariello; Szuhuei Wu Wilson; Prabhakar Puthe 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB

## Abstract Inflammation induces the NF‐κB dependent protein A20 in human renal proximal tubular epithelial cells (RPTEC), which secondarily contains inflammation by shutting down NF‐κB activation. We surmised that inducing A20 without engaging the pro‐inflammatory arm of NF‐κB could improve outcom