Epidemiologic studies have established clear variations in the occurrence of neural tube defects (NTDs) associated with demographic and other factors. Methods of counting NTD-affected pregnancies and other birth defects rely on multiple sources of information such as hospital records and birth certi
Epidemiology of neural tube defects
โ Scribed by Laura E. Mitchell
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 89 KB
- Volume
- 135C
- Category
- Article
- ISSN
- 1552-4868
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Neural tube defects are a complex, heterogeneous, and multifactorial group of disorders. In humans it is estimated that 80% of neural tube defects are ''multifactorial'' and are influenced by both genetic and environmental factors. It appears that 70% of neural tube defects in humans are related to
We reviewed the genetic variants and strains of mice that are used as models for neural tube defects (NTD) in humans. Over 40 genetic defects in mice cause obvious risk of NTD, but most are syndromic and many are lethal to embryos. Only a subset is similar to the common, nonsyndromic, genetically co