Epidemiology and causation of human renal disease: the case of aristolochic acid nephropathy
β Scribed by Arlt, Volker M.
- Book ID
- 122661201
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 57 KB
- Volume
- 221
- Category
- Article
- ISSN
- 0378-4274
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## Abstract Aristolochic acid (AA) is the causative agent of urothelial tumors associated with AA nephropathy and is also implicated in the development of Balkan endemic nephropathyβassociated urothelial tumors. These tumors contain AAβcharacteristic __TP53__ mutations. We examined gene expression
## Abstract The proposal has been put forward that the primary cause of Balkan endemic nephropathy (BEN) is exposure to food crops contaminated with seeds of __Aristolochia__ spp, which contain high levels of aristolochic acids (AA). Recently, tumour DNA samples from patients with BEN were found to