## Abstract To clarify the genetic background of amyotrophic lateral sclerosis (ALS)/parkinsonism–dementia complex (PDC) of the Kii peninsula, Japan (Kii ALS/PDC), we performed extended mutation analyses of three patients with pathologically diagnosed Kii ALS/PDC. Direct sequencing analyses were pe
Epidemiological surveillance of amyotrophic lateral sclerosis and parkinsonism-dementia in the commonwealth of the Northern Mariana Islands
✍ Scribed by Dr R. T. Yanagihara; R. M. Garruto; D. C. Gajdusek
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 698 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0364-5134
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📜 SIMILAR VOLUMES
An update of the endemic parkinsonism-dementia complex (PDC) frequently associated with amyotrophic lateral sclerosis (ALS) in the high prevalence ALS focus of the Kii peninsula of Japan is presented. The initial symptom was parkinsonian gait or hypobulia/amnesia, which was followed by akinesia, rig
## Abstract Amyotrophic lateral sclerosis‐parkinsonism dementia complex (ALS/PDC) is a distinct neurodegenerative disorder characterized by ALS pathology with neurofibrillary tangles (NFTs) in the spinal cord and brain. Recent clinical studies have revealed a high incidence and a high familial occu