✦ LIBER ✦

Epidemiologic aspects of Santa Marta hepatitis over a 40-year period

✍ Scribed by Bernardo Buitrago; Stephen C. Hadler; Hans Popper; Swan N. Thung; Michael A. Gerber; Robert H. Purcell; James E. Maynard

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 483 KB
Volume: 6
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840060611

No coin nor oath required. For personal study only.

✦ Synopsis

hepatitis has been recognized as an unusual type of severe hepatitis occurring in northern Colombia since 1930. Liver specimens from a historic viscerotomy series, used by Gast-Galvis to identify cases and describe epidemiologic features of this disease, were available for review and histopathologic staining for 6- virus. Of 86 liver specimens examined from cases of fulminant Santa Marta hepatitis, 81 showed a distinct histopathologic picture, in various stages of progression, with features of eosinophilic necrosis, microvesicular fat infiltration of the liver parenchyma and morula cells; 69% were positive for &antigen by immunoperoxidase staining. This disease occurred predominantly in several small towns within 50 km of Santa Marta, with mortality reaching 1.25 per 1,000 inhabitants per year during the 1940's. Children under age 15 were most commonly affected and males affected twice as frequently as females. Liver specimens obtained from children, or within 15 hr of death, or which showed early histologic stages of disease were most likely to be positive for 6antigen.

This and the accompanying study confirm the existence of a distinct type of fulminant hepatitis in Colombia for over 50 years. The epidemiologic and histopathologic features are comparable to severe hepatitis in Venezuela Indians and in the Amazon basin of Brazil, suggesting that all are caused by 6-superinfection of hepatitis B virus carriers.

📜 SIMILAR VOLUMES

Mutation of the Parkin gene in a Persian

Mutation of the Parkin gene in a Persian family: Clinical progression over a 40-year period

✍ Jordi Clarimon; Janel Johnson; Ruth Djaldetti; Dena Hernandez; Nobutaka Hattori; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB

## Abstract We report on an Israeli family originating from Iran in which 4 of 7 brothers born from a consanguineous marriage had juvenile Parkinsonism. Linkage analysis of markers covering the autosomal recessive juvenile Parkinsonism (AR‐JP, PARK2, __Parkin__ gene, OMIM #602544) gene resulted in

Urinary tract infections in the city of

Urinary tract infections in the city of Florence: Epidemiological considerations over a twenty-year period

✍ G. Corti; E. Giganti; F. Paradisi; P. Nicoletti 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 488 KB

Our study of significant bacteriurias indicated that the worldwide shift in the etiology of infections also holds true for the Florence area. In a twenty-year period , we noted a decreased frequency of Gram-negative bacilli, particularly of the family Enterobacteriaceae, and a significant increase o

Reappraisal of the epidemiology of giant

Reappraisal of the epidemiology of giant cell arteritis in Olmsted County, Minnesota, over a fifty-year period

✍ Salvarani, Carlo ;Crowson, Cynthia S. ;O'Fallon, W. Michael ;Hunder, Gene G. ;Ga 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 2 views

## Objective: To investigate time trends in the incidence and survival of giant cell arteritis (gca) over a 50-year period in olmsted county, minnesota. ## Methods: Using the unified record system at the mayo clinic, we identified all incident cases of gca first diagnosed between 1950 and 1999. i

Molecular epidemiology of human respirat

Molecular epidemiology of human respiratory syncytial virus subgroup A over a six-year period (1999–2004) in Argentina

✍ Mariana Viegas; Alicia S. Mistchenko 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB

Evolution over a 10 year period of the e

Evolution over a 10 year period of the epidemiological profile of 1,726 newly diagnosed HCV patients in Belgium

✍ Christiane Gérard; Jean Delwaide; Dolores Vaira; Boris Bastens; Benoît Servais; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB

## Abstract In order to evaluate the future burden of hepatitis C, there is a need to quantify the evolution with time of some crucial parameters such as disease frequency and age, modes of infection and infecting genotypes of patients presenting for the first time at consultation. The yearly evolu

Changing epidemiology of nasopharyngeal

Changing epidemiology of nasopharyngeal carcinoma in Hong Kong over a 20-year period (1980–99): An encouraging reduction in both incidence and mortality

✍ Anne W.M. Lee; William Foo; Oscar Mang; W.M. Sze; Rick Chappell; W.H. Lau; W.M. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 90 KB

## Abstract Epidemiological data from the Hong Kong Cancer Registry for the period 1980–99 were analyzed. Altogether 21,768 new cases of nasopharyngeal carcinoma (NPC) and 8,664 related deaths were registered. In both genders, the peak incidence occurred in the 50–59 years age group, and this age d