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EPCAM germline and somatic rearrangements in lynch syndrome: identification of a novel 3′ EPCAM deletion

✍ Scribed by Spaepen, Marijke; Neven, Esther; Sagaert, Xavier; De Hertogh, Gert; Beert, Eline; Wimmer, Katharina; Matthijs, Gert; Legius, Eric; Brems, Hilde

Book ID
120524154
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
864 KB
Volume
52
Category
Article
ISSN
1045-2257

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## Abstract It was shown that Lynch syndrome can be caused by germline hypermethylation of the __MLH1__ and __MSH2__ promoters. Furthermore, it has been demonstrated very recently that germline deletions of the 3′ region of __EPCAM__ cause transcriptional read‐through which results in silencing of