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Epac- and Rap-independent ERK1/2 phosphorylation induced by Gs-coupled receptor stimulation in HEK293 cells

โœ Scribed by Jens Henrik Norum; Hoda Dawood; Raymond R. Mattingly; Dagny Sandnes; Finn Olav Levy


Book ID
118442114
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
468 KB
Volume
581
Category
Article
ISSN
0014-5793

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon