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EP4 prostanoid receptor-mediated vasodilatation of human middle cerebral arteries

✍ Scribed by Richard J Davis; Colin E Murdoch; Mozam Ali; Stuart Purbrick; Rivka Ravid; Gordon S Baxter; Nick Tilford; Robert L G Sheldrick; Kenneth L Clark; Robert A Coleman

Book ID: 110008171
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 160 KB
Volume: 141
Category: Article
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0705645

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## Abstract The lipid mediator prostaglandin E~2~ (PGE~2~) exhibits diverse biologic activity in a variety of tissues. Four PGE~2~ receptor subtypes (EP1–4) are involved in various physiologic and pathophysiologic conditions, but differ in tissue distribution, ligand‐binding affinity, and coupling