## Abstract To cast light on mechanisms underlying development of urothelial carcinomas (UCs) of the urinary bladder associated with Schistosomiasis, we immunohistochemically analyzed the relationship between oxidative stress markers, DNA single strand breaks (ssDNA) which could also measure the le
Eosinophilic infiltrates in carcinoma of the urinary bladder unassociated with schistosomiasis
โ Scribed by A. J. Tiltman
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 299 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0022-3417
No coin nor oath required. For personal study only.
โฆ Synopsis
Two hundred and twenty-four biopsies from 151 patients with urinary bladder neoplasms have been studied in order to investigate the incidence of and possible causes for the infiltration of eosinophils. Cases of schistosomiasis were excluded from this study. Of these biopsies, 16 showed a heavy infiltrate 26 a moderate, 61 minimal and 121 no eosinophilic infiltrate. No correlation could be found between the degree of infiltrate and age, sex or tumour type. There was some statistically significant correlation between the eosinophilic infiltrate and stromal invasion and/or tumour necrosis. There was a strong statistical correlation between this infiltrate and previous trauma (biopsy) which was supported by the study of bladder biopsies from patients without neoplasms.
๐ SIMILAR VOLUMES
Patients with schistosomiasis of the urinary bladder (SB) associated with carcinoma of the bladder (SCB) or carcinoma of the prostate (SCP) have a variety of immunologic abnormalities, including the presence of HLA-DR+ and interleukin-2 receptor-positive (IL-2R+) T-lymphocytes in circulating blood.
## BACKGROUND. To the authors' knowledge, the long term follow-up of patients with carcinoma in situ of the urinary bladder is limited. ## METHODS. The authors studied 138 patients diagnosed with urothelial carcinoma in situ of the bladder at the Mayo Clinic between 1972-1979. All the histologi