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Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor

โœ Scribed by Hideki Mochida; Michino Takagi; Hirotaka Inoue; Tsunehisa Noto; Koji Yano; Kotomi Fujishige; Takashi Sasaki; Keizo Yuasa; Jun Kotera; Kenji Omori; Kohei Kikkawa


Book ID
114015198
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
158 KB
Volume
456
Category
Article
ISSN
0014-2999

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LY301317 ((4r)-(-)-4-(dipropylamino)-6-(5-oxazolinyl)-1, 3,4,5-tetrahydrobenz[c,d]indole) has high affinity for the 5-HT 1A receptor and weak affinity for the 5-HT 1D and histamine-H 1 receptors. No significant affinity was found for the other amine receptors studied. In rats, LY301317 produced pote