✦ LIBER ✦
Enzymic reactions in heterogeneous phase, preparation of 17a, 20β, 21-trihydroxypregn-4 [14C] en-3, 11-dione
✍ Scribed by Pietro Cremonesi; Maria Maddalena Casellato
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- French
- Weight
- 219 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The preparation of 17a, 208, 21‐trihydroxypregn‐4 [^14^C] en‐3, 11‐dione, in quantitative yields, has been achieved u‐sing enzymic reduction of cortisone [^14^C] in water‐organic solvent heterogeneous system. Since small volumes and little amount of enzyme are required to carry out the reaction, as comppared to the enzymic preparation using an homogeneous aqueous phase, the methodology is useful for preparative purposes.