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Enzymic properties of a new mechanism-based substrate for dihydrofolate reductase

✍ Scribed by Thibault, Vincenza; Koen, Mark J.; Gready, Jill E.

Book ID
126328885
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
959 KB
Volume
28
Category
Article
ISSN
0006-2960

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πŸ“œ SIMILAR VOLUMES

Electron redistribution on binding of a
Electron redistribution on binding of a substrate to an enzyme: Folate and dihydrofolate reductase
✍ JΓΌrgen Bajorath; David H. Kitson; George Fitzgerald; Jan Andzelm; Joseph Kraut; πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 893 KB

## Abstract The migration of electron density of a substrate (folate) on binding to an enzyme (dihydrofolate reductase) is studied by a quantum‐mechanical method originally developed in solid state physics. A significant polarization of the substrate is induced by the enzyme, toward the transition