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Enzymes of purine nucleotide metabolism in human lymphocytes

✍ Scribed by J.P.R.M. Van Laarhoven; G.Th. Spierenburg; C.H.M.M. De Bruyn


Book ID
118898119
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
548 KB
Volume
39
Category
Article
ISSN
0022-1759

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In order to study if enzymes of purine metabolism could be used as cell markers in B-chronic lymphocytic leukemia (B-CLL), the activities of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5'-nucleotidase (5") were repeatedly measured in blood mononuclear cells from B-CLL patie

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Inherited deficiencies of adenosine deaminase and purine nucleoside phosphorylase have been found to be associated with certain immunodeficiency syndromes which are characterized by deficiencies of mature peripheral lymphocytes. The immunodeficiency states associated with these enzyme deficiencies a