𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enzymes in asymmetric synthesis: Effect of reaction media on the PLE catalysed hydrolysis of diesters

✍ Scribed by Giuseppe Guanti; Luca Banfi; Enrica Narisano; Renata Riva; Sergio Thea

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
233 KB
Volume
27
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Organic cosolvents and other addenda can influence

the rate and the enantioselectivity of pig Ziver esterase catalysed hydroZysis of meso diacetates and diesters, the magnitude of the effect being strongZy dependent on the nature of substrate.

Dissymmetrization of meso diesters and diacetates through enzyme catalysed hydrolysis is a powerful tool for preparation of chiral "building blocks" to be used in the synthesis of natural products.

3 In particular, pig liver esterase (PLE) has been extensively employed due to its wide specificity. Unfortunately, however, enantiomeric excesses are not always high, thus

limiting the enzyme's potential utility.

πŸ“œ SIMILAR VOLUMES

Effect of solvent on the reactions of co
Effect of solvent on the reactions of coordination complexes: Part 15: Base hydrolysis ofCis-(Chloro)(benzimidazole)-Bis-(ethylenediamine)cobalt(III) ion in mixed solvent media
✍ Anadi C. Dash; Neelamadhab Dash πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 390 KB πŸ‘ 1 views

The kinetics of base hydrolysis of the cis-(chloro)-(benzimidazole)bis(ethylenediamine) cobalt(II1) ion was investigated in Methanol-water and Ethyleneglycol-water media of varying compositions and at isodielectric conditions (Ds = 61 at 25Β°C) in isopropanol-and Acetonitrilewater media at 35Β°C in th

Synthesis and behaviour study of amphiph
Synthesis and behaviour study of amphiphilic polyvinylimidazolium salts in aqueous media: Effects of the microdomains on a bimolecular reaction involving hydrophobic reactants
✍ Christine Damas; Alain Brembilla; Francis Baros; Marie-Laure Viriot; Pierre Loch πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 English βš– 625 KB

Homopolymers of 3-alkyl-l-vinylimidazolium bromides series have been prepared by free radical polymerization in aqueous solution or in benzene. The tendency of aggregation of these water soluble polymers was studied by viscosity measurements and fluorescence probes which have revealed the formation

Effects of solvents on the reactions of
Effects of solvents on the reactions of coordination complexes: Part 20. Kinetics and mechanism of base hydrolysis of (Ξ±Ξ²S) (Salicylato) (Tetraethylenepentamine) Cobalt(III) in aquo-organic solvent media
✍ Anadi C. Dash; Guru C. Pradhan; Raghunath Acharya πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 595 KB

The kinetics of base hydrolysis of (CUPS) (salicylato) (tetraethylenepentamine) cobalt(II1) have been investigated in aquo-organic solvent media at 15.0 f t, "C < 40.0, and I = 0.10 mol dm (C104-) using propane-2-01 (570% v/v), t-butanol(560% v/v), acetone (570% v/v, acetonitrile (550% v/v), and eth

Effects of solvent on the reactions of c
Effects of solvent on the reactions of coordination complexes: Part 17. Kinetics and mechanism of base hydrolysis of (Ξ±Ξ²S) (salicylato) (tetraethylenepentamine)cobalt (III) in methanol + water and dimethylsulphoxide + water media
✍ Anadi C. Dash; Prafulla K. Das πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 611 KB

The base hydrolysis of (apS) (salicylato) (tetraethylenepentamine)cobalt(III) has been investigated in MeOH + water and DMSO + water media (0-70% (viv) cosolvents) at 20.0 I t"C I 35.0 and I = 0.10 mol dm-3 (clod-). The phenoxide species [(tetren)Co02CC,H40]' undergoes both OH--independent and OH--c