Enzymes and protecting group chemistry
β Scribed by Tanmaya Pathak; Herbert Waldmann
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 857 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1367-5931
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β¦ Synopsis
Enzymatic protecting group techniques are increasingly finding their use in almost all areas of synthetic organic chemistry. Some of the recent papers have dealt with the use of such protecting groups in combination with classical methods. The modification of known protecting groups to increase the efficiency and selectivity of deprotection is on the rise. The methodology needs to be explored more intensively and systematically to realise its full potential.
π SIMILAR VOLUMES
We introduce benzylsulfonyl (Bns) as a valuable protecting group in phenol chemistry. Bns proved to be stable under drastic reaction conditions and towards many common reagents. The deprotection proceeds quantitatively using catalytic hydrogenolysis. Additionally the Bns deactivating properties make
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