Enzyme systems involved in the formation of reactive metabolites in the renal medulla: Cooxidation via prostaglandin H synthase*1

Human hepatic and renal microsomes, cyto

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:Cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer

✍ Marie Stiborová; Eva Frei; Petr Hodek; Manfred Wiessler; Heinz H. Schmeiser 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 139 KB

## Abstract Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's suscep