Enzyme patterns in non-neoplastic and spontaneously transformed tissue culture cells: A histochemical and biochemical study

Grb2 overexpression in nuclei and cytopl

Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimens

✍ Verbeek, Bianca S.; Adriaansen-slot, Sabrina S.; Rijksen, Gert; Vroom, Thea M. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 714 KB

In 20-30 per cent of human breast cancers, the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and c-erbB2 are overexpressed. This overexpression leads to increased mitogenic signalling and is correlated with poor prognosis. Overexpression of associated adaptor proteins, like Grb2,